CHIRALPLATE – Special layer for TLC enantiomer separation. Separation based on ligand exchange, i. e. formation of ternary mixed-ligand complexes with Cu(II) ions. Differences in the stability of the diastereomeric complexes cause chromatographic separation. Available as glass plates with fluorescent indicator. A review on the application of CHIRALPLATE has been given by K. Günther [J. Chromatogr. 448 (1988) 11–30].
| Method | Thin layer chromatography (HPTLC/TLC) |
|---|---|
| Phase | CHIRALPLATE |
| Base material | Glass plates coated with impregnated silica gel |
| Surface chemistry | Silica gel impregnated with Cu(II) ions and a chiral selector (proline derivative) |
| Mode | Reversed phase (RP) with ligand exchange |
| Layer thickness | 0.25 mm |
| Layer hardness | Standard, soft |
| UV indicator | Yes |
| Support material / backing | Glass |
| Particle type | Fully porous particles (FPP) |
| Particle shape | Irregular |
| Pore volume | Not available or not applicable |
| Binder | Yes |
| pH stability | 2.0–8.0 |
| Recommended application(s) | Amino acids, Dipeptides, Enantiomers, Lactones, N-formylamino acids, N-methylamino acids, Thiazolidine derivatives, α-alkylamino acids, α-hydroxycarboxylic acids |
| Temperature stability | High |
| Storage temperature | 15–25 °C / 59–77 °F |
| Hazardous material | No |
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